Research & development > Skin / Cutaneous Substitute
Skin / Cutaneous Substitute
Novotec successfully achieved several Research projects, in collaboration with academics, with small businesses and with international leading companies.
Involved in clinical issues as well as in dermatological and cosmetic issues, skin is the subject of many studies about renewal, remodeling, healing and tissue repair. Based on its technical and scientific skills, Novotec stepped in Research projects about innovative products. Formulations of creams and oils were tested on cultured-cells and in vitro tissues.
Novotec also took part in the follow-up of experimental pre-clinical and clinical studies: assessment of cutaneous burns after irradiation, effects of pharmaceutical molecules on pathological skins (such as psoriasis), laser treatment on lesions resulting from surgery or irradiation.
Novotec also develops research programs on cutaneous tissue engineering, in collaboration with French and foreign companies: characterization of dermal, epidermal and dermo-epidermal substitutes, grafts of the cutaneous substitutes on nude mice (agreement of surgery on small animals, consortium with several companies and laboratory animal house for the management of a complete preclinical project) and analysis of the samples during preclinical studies. The perfect command of the various tissular and cellular analysis methods leads to carry out kinetic studies of biocompatibility and integration of the cutaneous substitutes. The key steps of the cutaneous repair (neo-vascularization, re-epithelization, matricial remodeling…) could be described from both a genic and a protein point of view. These analyses allowed to answer three essential questions: who, when and where?
Moreover, Novotec collaborated on studies about biocompatibility and deterioration of biomaterials. After graft or injection of these biomaterials in the skin (dressings, resorbable and permanent dermal fillers …), standard colorations (HES, Masson-Goldner’s trichrome) and specific colorations (MGG) were carried out on paraffin embedded tissues or methylmethacrylate resin (MMA) embedded tissues. Qualitative and semi-quantitative methods allowed estimating the damage of the biomaterials and the inflammatory reaction.
Thanks to its experience, Novotec is a specialist in the skin and cutaneous substitutes field.
